Ameliorative Effect of Beraprost Sodium on Celecoxib Induced Cardiotoxicity in Rats

Selective COX-2 inhibitors are most widely used analgesic and anti-inflammatory drugs;however, its maximal use is highly associated with various serious abnormal cardiovascularevents. Beraprost sodium (BPS), prostacyclin analogue has been shown to vasodilatory,antiplatelates, anti-inflmmatory, and antioxidant activity. The objective of the present study wasto evaluate the effect of BPS on celecoxib cardiotoxicity in rats. Toxicity was induced in maleAlbino rats (250-280 g) by celecoxib (100 mg/kg/day). BPS (30 μg/kg/day) was administeredalone and in combination with celecoxib for 14 days and various biochemicals, hemodynamic,left ventricular, biochemical, and histopathological parameters were studied. Cardiotoxicityof celecoxib was revealed by a significant increase in serum lactate dehydrogenase(LDH), troponin-T (Tn-T), tumor necrosis factor-α (TNF- α), creatine kinase-MB (CK-MB)and systolic blood pressure (SBP), left ventricular end diastolic pressure (LVEDP), LV (dp/dt)max, and LV (dp/dt)min as well as tissue thiobarbituric acid reactive substance (TBARS)and a significant decrease in tissue reduced glutathione (GSH). However, treatment withBPS reversed these alteration in LDH, Tn-T, TNF-α, CK-MB, SBP, LVEDP, LV (dp/dt)max,LV (dp/dt)min, TBARS and GSH levels. The histopathological study in cardiac left ventriclerevealed protection of myocardium as manifested reduction of fibrosis by abolition of collagendeposition when celecoxib was combined with beraprost sodium. It could be concluded thatberaprost sodium may prove a useful adjunct in patients being prescribed celecoxib.